Research
I’m working on characterizing the statistical computations that biological systems (brains, cells, otherwise) perform to autonomously discover and adapt to structure in the world from finite experiences.
I’m also interested in developing artificial systems that can do the same- aiming to automate some aspects of the scientific process.
I approach both of these directions using tools from information theory and probabilistic machine learning.
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Selected Projects
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Bayesian Complementary Learning Systems >
Bahti Zakirov,
Gašper Tkačik
Computational and Systems Neuroscience (COSYNE), 2026
We investigate a normative role for episodic replay in systems consolidation in i) enabling routing
experiences for consolidation to appropriate schemas and ii) shaping schemas' inductive biases. This
extends complementary learning systems views of Hippocampal-Neocortical memory consolidation.
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Meta-Learning Theory-Informed Inductive Biases using Deep Kernel Gaussian Processes >
Bahti Zakirov,
Gašper Tkačik
International Conference on Learning Representations (ICLR), 2026
pdf
We developed a Bayesian meta-learning framework to construct flexible probabilistic models
representing structure from neuro-theory knowledge. These theory-surrogate models resulted in both an
inductive bias to improve data-driven predictive fits on real neural data, and a more automated way
to validate and update the theory itself from the data using exact Bayesian model comparison.
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Active perception during angiogenesis: filopodia speed up Notch selection of tip cells in silico and in vivo
Bahti Zakirov,
Georgios Charalambous,
Raphael Thuret,
Irene M. Aspalter,
Kelvin Van-Vuuren,
Thomas Mead,
Kyle Harrington,
Erzsébet Ravasz Regan,
Shane Paul Herbert,
Katie Bentley
Philosophical Transactions of the Royal Society, B, 2021
pdf
We studied how endothelial cells use their embodiment and sensorimotor coordination to add
informational structure to inputs from their local chemical environment (i.e. "Active Perception") in
order to facilitate adaptive behaviour. This active perception speeded up Notch-mediated tip-cell
selection, the timing of which is crucial for blood vessel morphology.
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